School of Medicine

Wayne State University School of Medicine

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George Yoo, M.D.
Research Educator track, full time
Chief Medical Officer, Karmanos Cancer Institute
Physician in Chief, Karmanos Cancer Institute
Director of Clinical Affairs, Karmanos Cancer Institute

Wayne State University - Medicine
540 E. Canfield
Detroit, MI 48201

Additional clinical office:
Weisberg Clinic
21995 Northwestern Highway
Farmington Hills, MI  48334



Dr. George Yoo is a head and neck surgical oncologist and a Professor in the departments of Otolaryngology-Head and Neck Surgery at Wayne State University (WSU) and the Karmanos Cancer Center (KCC).  Dr. Yoo is an expert in the surgical management of head and neck (mouth and throat) cancers along with melanoma, thyroid, parotid and sinus tumors.  Dr. Yoo has been selected as �The Best Doctors in America�, �HOUR Detroit Magazine � Top Doctors� and �Who�s Who in America�. 

At KCC, Dr. Yoo is the Chief Medical Officer and Director of Clinical Affairs.  He serves as the Chair of the Surgery Committee in the Southwest Oncology Group (SWOG).

Dr. Yoo completed his residency in Otolaryngology-Head and Neck Surgery at Johns Hopkins Hospital (JHH) in 1995 and then completed a fellowship at JHH in 1996.  He is a diplomat of the American Board of Otolaryngology-Head and Neck Surgery.  Dr. Yoo�s current research interests include gene therapy and surgical adjuvant therapy for head and neck cancer.  He has published over 70 articles and 6 chapters on head and neck cancer. 

Awards & Honors

The Best Doctors in America, 2005-2015  (Best Doctors is national organization that chooses awardees by peer-review-based evaluation by surveying physician.)

Detroit Super Doctors, 2014

Castle Connolly Medical Ltd., America’s Top Doctor, 2013

Areas of Interest
Head and Neck Surgical Oncology, Free flap reconstruction.
Other Information

Grants (last 5 years)

NCI NIH, 5P50 CA 097248-7, 10%  "SPORE and Head and Neck Cancer; The Molecular Basis of Head and Neck Cancer Biology Treatment and Prevention" Co-Investigator, (PI: Gregory Wolf, MD) 1/1/09-12/31/15
Provide scientific direction and coordination for the implementation and quality control of the study. 

NCI-Southwest Oncology Group, cooperative group grant, 10%, Co-Investigator.  1/01/06 - 12/31/14
Provide surgical leadership of the administrative and scientific functions of SWOG.

NCI-Southwest Oncology Group, 10%, Southwest Oncology Group, Wayne State University institutional grant, Co-Investigator.  1/01/04 - 12/31/14
Provide leadership of the administrative and scientific functions of SWOG.

Application No: 60/436,754 �Overexpression of exogenous p53 on HPV-immortalized and carcinogen transformed keratinocytes. Inventor: George H Yoo 

Selected Publications

Selected original observations in refereed journals �(last 5 years)

Lin HS, Rowley JA, Folbe AJ.,Yoo GH, Badr MS, Chen W: �Transoral Robotic Surgery for Treatment of Obstructive Sleep Apnea: �Factors Predicting Surgical Response. �Laryngoscope. �2014 Oc24. �Doi: �10.1002/lary.24970. [Epub ahead of print] PMID: �25346038. �

Y. Xi, D.M. Garshott, A.L. Brownell,G.H. Yoo, H.S. Lin, T.L. Freeburg, N.G. Yoo, R.J. Kaufman, M.U. Callaghan, A.M. Fribley. �Cantharidins Induce ER Stress and a Terminal Unfolded Protein Response in OSCC. �J Dent Res published online 25 November 2014; DOI 10.1177/0022034514559376.

Soares D, Folbe A,Yoo GH, Badr S, Rowley JA, Lin HS. �Drug Induced Sleep Endoscopy vs. Awake Mullers Maneuver in the Diagnosis of Severe Upper Airway Obstruction. �OtolaryngologyHead and Neck Surgery Volume 148 No 1 (151-156), January 2013.

Paximadis P,Yoo G, Lin HS, Jacobs J, Sukari A, Dyson G, Christensen M, Kim H. �Concurrent Chemoradiation Improves Survival in Hypopharyngeal Cancer. �Int J Radiation Oncology Biol Phys 2012; 82(4):1515-1521.

Soares D, Sinawe H, Folbe A,Yoo GH, �Badr S, Rowley JA, Lin HS. �Lateral Oropharyngeal Wall and Supraglottic Airway Collapse Predict Failure in Sleep Apnea Surgery. � Laryngoscope, 122: 473-479. �2012.

Zyad Kafri, Lance Heilbrun, Ammar Sukari,George Yoo, John R. Jacobs, Ho-Sheng Lin, Heather Mulrenan, Daryn Smith, Omer Kucuk. �Phase II Study of Gemcitabine and Docetaxel Combination (GEMDOC) in Patients with Previously Treated Recurrent or Metastatic Squamous Cell Carcinoma of the Head �and �Neck. �ISRN Oncology. �2012. �

Ho-Sheng Lin, Adam Folbe, Michael Carron, Giancarlo Zuliani, Wei Chen,George Yoo, Robert Mathog. �Single-Incision Trans-Axillary Robotic Thyroidectomy: �Challenges and Limitations in a North American Population. �OtolaryngologyHead and Neck Surgery Volume 147 Issue 6, 1041-1046. �December 2012.

McCormick M; Folbe AJ; Lin HS; Hooten J;Yoo GH; Krouse JH. Site involvement as a predictor of airway intervention in angioedema. Laryngoscope, 121(2):262-6, 2011.

Yoo GH; Subramanian G; Ezzat WH; Tulunay OE; Tran VR; Lonardo F; Ensley JF; Lonardo F; Kim H; Won J; Stevens T; Zumstein LA; Lin HS. The Enhancement of Ad-p53 by Docetaxel Delivered Intratumorally in Head and Neck Squamous Cell Carcinoma. Am J Oto, 31(2):78-83, 2010.�

Yoo GH; Kafri Z; Ensley JF; Lonardo F; Kim H; Folbe A; Won J; Stevens T; Lin HS. XRP6258 Induced Gene Expression Patterns in Head and Neck Cancer Carcinoma. Laryngoscope, 120:11141119, 2010.�

Books/Book Chapters (last 5 years)

Michael Z Chen, Robert H Mathog, Andrew M Fribley, George H Yoo. �Oral Cancer: Location, staging, surgical management and outcomes. �In Targeting Oral Cancer. � submitted to Springer, �May, 2015